Эффективность нового антигельминтного препарата Supramil® таблетки при кишечных гельминтозах собак и кошек

В.А. Оробец1, доктор ветеринарных наук, профессор, заведующий кафедрой терапии и фармакологии;

О.И. Севостьянова1, кандидат биологических наук, доцент кафедры терапии и фармакологии;

И.В. Заиченко2, кандидат ветеринарных наук, главный ветеринарный врач;

С.В. Мукасеев3, кандидат ветеринарных наук, ветеринарный врач;

О.А. Зейналов4, кандидат биологических наук, главный специалист по науке.

1 Федеральное государственное бюджетное образовательное учреждение высшего образования Ставропольский государственный аграрный университет (355017, РФ, г. Ставрополь, пер. Зоотехнический 12)

2 Ветеринарный центр «На Пирогова», (355045, РФ, г. Ставрополь, ул. Пирогова, д. 24/2).

3 ООО «АГ «Аспект» (117246, РФ, г. Москва, Научный проезд, д. 20, стр. 3, помещение 6).

4 ООО «НПК «СКиФФ» (117246, РФ, г. Москва, Научный проезд, д. 20, стр. 3, помещение 204).

Изучена эффективность нового антигельминтного препарата для собак и кошек Supramil® таблетки. Терапевтическая эффективность препарата Supramil® таблетки после однократного применения спонтанно инвазированным кишечными нематодами и/или цестодами собакам и щенкам в дозе 2,5 мг/кг по R-празиквантелу и 0,5 мг/кг по мильбемицину оксиму при токсокарозе, токсаскариозе, анкилостомозе, трихурозе, дипилидиозе, тениозе, мезоцестоидозе, а также при смешанных нематодозно-цестодозных инвазиях составила 100 %. Терапевтическая эффективность препарата Supramil® таблетки после однократного применения спонтанно инвазированным кишечными нематодами и/или цестодами кошкам и котятам в дозе 2,5 мг/кг по R-празиквантелу и 2,0 мг/кг по мильбемицину оксиму при токсокарозе, анкилостомозе, трихурозе, дипилидиозе, тениозе и смешанных нематодозно-цестодозных инвазиях составила 100 %. Таким образом, Supramil® таблетки является высокоэффективным средством лечения наиболее часто встречающихся кишечных гельминтозов собак и кошек.

Ключевые слова: эффективность, Supramil® таблетки, R-празиквантел, мильбемицина оксим, собаки, щенки,  кошки, котята, кишечные нематоды, кишечные цестоды, смешанная инвазия.


Efficacy of the new anthelmintic drug Supramil® tablets in intestinal helminthiases of dogs and cats

V.А. Оrobets1, Grand PhD of Veterinary Sciences, professor, Head of Department of therapy and pharmacology (orobets@yandex.ru);
O.I. Sevostyanova1, Ph.D. in Biology Science, Senior Lecturer Department of therapy and pharmacology (sevostyanova19@mail.ru);
I.V. Zaichenko2, PhD in Veterinary Science, the chief veterinarian» (igorzaichenko@mail.ru);
S.V. Mukaseev3, PhD in Veterinary Science, the veterinarian (mukaseev@aspect-ag.com);
O.A. Zeynalov4, PhD in Biology Science, chief science specialist.
1 Federal State Budget Educational Institution of Higher Education «Stavropol State Agrarian University» (12, Zootechnical side-street, Stavropol, RF, 355017).
2 Veterinary center «Na Pirogova» (24/2, Pirogova street, Stavropol, RF, 355045).
3 LLC «AG «Aspect» (ap. 6, build 3, h. 20, Nauchny pr, Moscow, RF, 117246).
4 LLC «SPC «SKiFF» (ap. 204, build 3, h. 20, Nauchny pr, Moscow, RF, 117246).

The effectiveness of a new anthelmintic drug for dogs and cats Supramil® tablets was studied.
Therapeutic efficacy of the drug Supramil® tablets after a single application of spontaneously infested intestinal nematodes and / or cestodes to dogs and puppies at a dose of 2.5 mg / kg for R-praziquantel and 0.5 mg / kg for milbemycin oxime was 100%.
Therapeutic efficacy of the drug Supramil® tablets after a single application of spontaneously infested intestinal nematodes and / or cestodes to cats and kittens at a dose of 2.5 mg / kg for R-praziquantel and 2.0 mg / kg for milbemycin oxime was 100%.
Thus, Supramil® tablets are a highly effective for the most common intestinal helminthiases of dogs and cats.

Keywords: efficacy, Supramil® tablets, R-praziquantel, milbemycin oxime, dogs, puppies, cats, kittens, intestinal nematodes, intestinal cestodes, mixed invasion.


References

1. Arxipov I.A., Arxipova D.R., Dirofilyarioz: monografiya [Dirofilariasis: monograph] Moscow, Rossel`xozakademiya, 2004, 194 p.

2. Arxipova D.R., Biologiya dirofilyarij i e`pizootologiya dirofilyarioza sobak v stepnoj zone yuga Rossii [Biology of dirofilariasis and epizootology of dirofilariasis of dogs in the steppe zone of southern Russia], spec. 03.00.19 "Parasitology", 16.00.03 –"Veterinary microbiology, virology, epizootology, mycology with mycotoxicology and immunology", Extended abstract of candidate’s thesis in Biol. Sc., N. Novgorod, 2003, 25 p.

3. Bogdanova T.V. Biologicheskie aspekty` parazitirovaniya Dirofilaria immitis u sobak v Astraxanskoj oblasti [Biological aspects of parasitizing Dirofilaria immitis in dogs in the Astrakhan region], spec. 03.00.19 "Parasitology", Extended abstract of candidate’s thesis in Biol. Sc., Astraxan`, 2010, 27 p.

4. GOST R 58090-2018 Klinicheskoe obsledovanie neproduktivny`x zhivotny`x. Obshhie trebovaniya [Clinical examination of unproductive animals. General requirements], date of introduction 2018-10-01, Moscow, Standartinform, 2018, 12 p.

5. Zoloty`x T.A. Dirofilyarioz domashnix plotoyadny`x Voronezhskoj oblasti (rasprostranenie, kliniko-gematologicheskaya xarakteristika, mery` bor`by` i profilaktiki) [Dirofilariasis of domestic carnivores of the Voronezh region (distribution, clinical and hematological characteristics, control and prevention measures): spec. 03.02.11 "Parasitology", candidate’s thesis in Vet. Sc. Voronezh, 2017, 125 p.

6. Konyaev S.V., Rasprostranenie Dirofilaria immitis v stranax by`vshego SSSR [Distribution of Dirofilaria immitis in the countries of the former USSR], Sovremennaya veterinarnaya medicina, 2019, No. 5, pp. 26-41.

7. Morozova L.F. Tixonova E.O., Zotova M.A., et al., Dirofilyariozy`: klinicheskaya kartina, diagnostika, lechenie, profilaktika [Dirofilariasis: clinical picture, diagnosis, treatment, prevention], Infekcionny`e bolezni: novosti, mneniya, obuchenie, 2018, Vol. 7, No. 4, pp. 90-96.

8. Orobecz V.A., Sevost`yanova O.I., Zaichenko I.V., Mukaseev S.V., Ocenka terapevticheskoj e`ffektivnosti suspenzii Prazitel® Osoby`j pri kishechny`x gel`mintozax shhenkov i kotyat [Evaluation of the therapeutic efficacy of Prazitel® suspension Special for intestinal helminthiasis of puppies and kittens], Rossijskij veterinarny`j zhurnal, 2019, No. 7, pp. 25-32.

9. Orobecz V.A., Mukaseev S.V., Zejnalov O.A., Toksikologicheskaya ocenka antigel`mintnogo preparata Supramil® tabletki dlya sobak i koshek [Toxicological evaluation of anthelmintic drug for dogs and cats Supramil® tablets], Veterinariya. 2022, No. 6, pp. 55-62.

10. Orobecz V.A., Sevost`yanova O.I., Zaichenko I.V., Mukaseev S.V., Zejnalov O.A., E`ffektivnost` novogo antigel`mintnogo preparata Supramil® tabletki pri kishechny`x gel`mintozax sobak i koshek [The effectiveness of the new anthelmintic drug Supramil® tablets for intestinal helminthiasis of dogs and cats], Rossijskij veterinarny`j zhurnal, 2022, No. 2, pp. 30-41.

11. Orobecz V.A., Sevost`yanova O.I., Zaichenko I.V., Mukaseev S.V., E`ffektivnost` novogo antigel`mintnogo preparata Prazitel® Osoby`j pri lechenii kishechny`x gel`mintozov sobak starshe 6 let [The effectiveness of the new anthelmintic drug Prazitel® Special in the treatment of intestinal helminthiasis of dogs older than 6 years], Rossijskij veterinarny`j zhurnal, 2018, No. 2, pp. 45-48.

12. Patent RU 2613490 C2. Kompoziciya na osnove R(-)-prazikvantela dlya lecheniya i profilaktiki gel`mintozov u teplokrovny`x. [Composition based on R(-)-praziquantel for the treatment and prevention of helminthiasis in warm-blooded], Patent owner: Limited Liability Company "Scientific and Production Company "SKiFF". Author: Zolotareva Vera Anatolyevna. Start of action: 2015.01.27. Publication: 2017.03.16. Submission: 2015.01.27. 

13. Patent RU 2722272 C1. Sredstvo dlya lecheniya i profilaktiki nematodozov i cestodozov u melkix domashnix zhivotny`x [A remedy for the treatment and prevention of nematodoses and cestodoses in small pets] Patent holder: Limited Liability Company "Scientific and Production Company "SKiFF". Authors: Kokorina Lyubov Mikhailovna, Zeynalov Orhan Ahmed ogly. Start of action: 2019.04.30. Publication: 2020.05.28. Submission: 2019.04.30.] 

14. Prazitel Osoby`j. Unikal`noe reshenie dlya profilaktiki i lecheniya gel`mintozov u koshek i sobak starshe 6 let [A unique solution for the prevention and treatment of helminthiasis in cats and dogs over 6 years old], VetPharma, 2017, No. 3 (37), pp. 20-27.

15. Sogrina A.V. Dirofilyarioz sluzhebny`x sobak v Permskom krae (rasprostranenie, serologicheskij monitoring, kariopaticheskoe dejstvie antigenov Dirofilaria immitis i protivoparazitarny`x preparatov) [Dirofilariasis of service dogs in the Perm Region (distribution, serological monitoring, karyopathic effect of Dirofilaria immitis antigens and antiparasitic drugs). spec. 03.02.11 "Parasitology"], Extended abstract of candidate’s thesis in Biol. Sc., Moscow, 2017, 147 p. 

16. Supryaga V.G., Starkova T.V., Sabgajda T.P., et al. Izuchenie dirofilyarioza v Rossii [Study of dirofilariasis in Russia], Osnovny`e dostizheniya i perspektivy` razvitiya parazitologii [Main achievements and prospects for the development of parasitology], Moscow, 2004, pp. 304-306.

17. Shinkarenko A.N., Kolesnikov P.V., E`kologiya dirofilyarioza sobak i morfofunkcional`naya dinamika ego oslozhneniya tromboe`mboliej legochnoj arterii [Ecology of canine dirofilariasis and morphofunctional dynamics of its complications by pulmonary embolism], Vestnik Volgogradskogo gosudarstvennogo universiteta, 2009, No. 2, pp. 244-248.

18. Shulyak B.F., Arxipov I.A., Nematodozy` sobak (zoonozy` i antropozoonozy`) [Nematodes of dogs (zoonoses and anthropozoonoses)], Moscow, KonsoMed, 2010, 495 p.

19. Yastreb V.B. Gel`mintozoonozy`: e`xinokokkoz i dirofilyarioz (biomorfologicheskie osobennosti vozbuditelej, sovershenstvovanie mer bor`by`) [Helminthozoonoses: echinococcosis and dirofilariasis (biomorphological features of pathogens, improvement of control measures). spec. 03.00.19 "Parasitology", Extended abstract of Doctor’s thesis in Vet. Sc., Moscow, 2009, 48 p.

20. Yastreb V.B., Dirofilyarioz sobak i cheloveka v Moskovskom regione [Dirofilariasis of dogs and humans in the Moscow region], Shnaucer segodnya, 2006, No. 2, pp. 23-25.

21. Yastreb V.B., Arxipov I.A., Rekomendacii po diagnostike, lecheniyu i profilaktike dirofilyarioza sobak v Moskovskom regione [Recommendations for the diagnosis, treatment and prevention of dirofilariasis of dogs in the Moscow region], Rossijskij parazitologicheskij zhurnal, 2008, No. 4, pp. 109–114. 

22. Andrews P., Thomas H., Pohlke R., Seubert J. Praziquantel, Med. Res. Rev., 1983, No. 3, pp. 147-200.

23. Cioli D., Pica-Mattoccia L., Basso A., Guidi A., Schistosomiasis control: Praziquantel forever?, Mol Biochem Parasitol., 2014, No. 195(1), pp. 23-29.

24. Meister I., Ingram-Sieber K., Cowan N., Todd M., Robertson M.N., Meli C., Patra M., Gasser G., Keiser J., Activity of praziquantel enantiomers and main metabolites against Schistosoma mansoni, Antimicrob Agents Chemother, 2014, Sep 30, No. 58(9), pp. 5466-5472.

25. Meyer T., Sekljic H., Fuchs S., Bothe H., Schollmeyer D., Miculka C., Taste, a new incentive to switch to (R)-Praziquantel in schistosomiasis treatment. PLoS Negl. Trop. Dis., 2009, No. 3, 357 р.

26. Olliaro P., Delgado-Romero P., Keiser J., The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer), J. Antimicrob. Chemother, 2014, No. 69(4), рр. 863-870.

27. Shuhua X., Binggui S., Chollet J., Tanner M., Tegumental changes in adult Schistosoma mansoni harboured in mice treated with praziquantel enantiomers, Acta Trop., 2000, Sep 18, No. 76(2), pp. 107-117.

28. Wu M.H., Wei C.C., Xu Z.Y., Yuan H.C., Lian W.N., Yang Q.J., Chen M., Jiang Q.W., Wang C.Z., Zhang S.J. et al., Comparison of the therapeutic efficacy and side effects of a single dose of levo-praziquantel with mixed isomer praziquantel in 278 cases of schistosomiasis japonica, Am. J. Trop. Med. Hyg., 2000, No. 45, рр. 345-349.

29. Xiao S., Shen B. Scanning electron microscope observation on tegumental alteration of Schistosoma japonicum induced by levo- and dextro-praziquantel. Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai, 1995, No. 13(1), pp. 46-50.